Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases

Veronika F. S. Pape, Nóra V. May, G. Tamás Gál, István Szatmári, Flóra Szeri, Ferenc Fülöp, Gergely Szakács* and Éva A. Enyedy* Dalton Trans., 2018, 47, 17032–17045 Abstract The anticancer activity of 8-hydroxyquinolines relies on complex formation with redox active copper and iron ions. Here we employ UV-visible spectrophotometry and EPR spectroscopy to compare proton dissociation and complex formation processes of the reference compound 8-hydroxyquinoline (Q-1) and three related Mannich bases to reveal possible correlations with biological activity. The studied Read More …

Our group was awarded an International Excellence (KH) OTKA grant

The Chemical Crystallography Group was awarded an International Excellence (KH) OTKA grant: “Research team with significant achievements of internationally outstanding impact “. Title: Supramolecular chemistry in solid state Principal Investigator: Petra Bombicz Participants: Nóra Veronika May Laura Nagyné Bereczki Roberta Palkó Tamás Holczbauer Abstract: Supramolecular chemistry is a highly interdisciplinary field of science covering chemical, physical and biological features. The supramolecular interactions are responsible for the self-assembly of molecules in liquid and solid states. Study of non-covalent interactions is crucial Read More …

Tamás Holczbauer has received a postdoctoral (PD) OTKA grant

Title: Supramolecular interactions and polymorphy, effect of temperature and pressure Abstract: Most of the appliances we use in everyday life are made of solid state materials for example drug, dye or casual objects. The function and lifetime of these objects are important. The understanding and the manipulation of secondary interactions in solid state may provide longer lifetime, different functions, new application for the objects. For example a new polymorph of a known drug may be more advantageous for human consumption, and less Read More …

Participation on the 31th European Crystallographic Meeting

  The 31st European Crystallographic Meeting, ECM31, of the European Crystallographic Association took place in the Palace of Exhibition and Congresses (PEC) in Oviedo, Asturias, from 22-27 August 2018. ECM31 was setting up an attractive programme covering the latest advances in crystallography and related sciences to attract young and senior scientists as well as companies and general public. Our group take part in the conference with two lectures and two posters and spent an unforgettable time in Oviedo, Spain. MS36-O5: Read More …

Tamás Holczbauer participated on the International Conference on Coordination Chemistry, Sendai, Japan

Tamas Holczbauer, as Inviting Lecturer, took part at the 43rd International Conference on Coordination Chemistry in Sendai, Japan and visited the Laboratorium of Prof. Masaki Kawano at the Tokyo Institute of Technology. Co-authors: L. Bereczki, N.V. May, D.V. Horváth, R. Palkó, T. Soós, P. Bombicz Title: New porous frameworks assisted by hydrogen and halogen bonds Abstract: The discovery of the metal organic frameworks (MOFs) has opened a new branch of research two decades ago. The covalent organic frameworks (COFs) were synthesized Read More …

FWO-MTA mobility project – first visit

By the help of a joint FWO-MTA mobility grant Dr. Vincent Ching and Kevin Nys visited our laboratory between 12-16 June 2018. The title of the project is “Structural analysis of copper-drug complexes relevant for chelation therapy by using pulsed-EPR and SXRD methods”. By the help of this FWO-MTA mobility grant our goal is to use pulsed-EPR methods to determine the couplings of far ligand protons for the CuL2 complexes of some hydroxypyridinecarboxylic acids (HPC) in order to detect the Read More …

Polymorphism of a porous hydrogen bond assisted ionic organic framework

Dániel Vajk Horváth, Tamás Holczbauer,* Laura Bereczki, Roberta Palkó, Nóra Veronika May, Tibor Soós and Petra Bombicz  CrystEngComm (2018), accepted for publication The polymorphism of a porous, non-covalently bonded ionic organic framework is reported. The framework is constructed by hydrogen bonding and anion⋯π interactions. In a solvatomorphic lattice, pyridine takes part in the framework formation. The role of molecular rigidity in framework construction is proven by analogous non-porous crystals, where polymorphism also appears. Full text

Professor Alajos Kálmán passed away on 26th December 2017.

He was one of the most prominent scientists in crystallography of our time. He was a most productive, widely respected, much-admired and inspiring scientific leader. We recall him as an enthusiastic and entertaining head, colleague, teacher and friend who loved crystallography and made a huge contribution to it. We treasure our memories with him. He will be missed by the crystallographic community. Biography