Impact of copper and iron binding properties on the anticancer activity of 8-hydroxyquinoline derived Mannich bases

Veronika F. S. Pape, Nóra V. May, G. Tamás Gál, István Szatmári, Flóra Szeri, Ferenc Fülöp, Gergely Szakács* and Éva A. Enyedy* Dalton Trans., 2018, 47, 17032–17045 Abstract The anticancer activity of 8-hydroxyquinolines relies on complex formation with redox active copper and iron ions. Here we employ UV-visible spectrophotometry and EPR spectroscopy to compare proton dissociation and complex formation processes of the reference compound 8-hydroxyquinoline (Q-1) and three related Mannich bases to reveal possible correlations with biological activity. The studied Read More …